Hi and welcome to the Community!
I second to Andrey - it should work just like any other card addition with leveraging non-disruptive upgrade procedure.
Of course caveats around this are endless:
- is the cluster properly configured? (there is a config checker on NOW looking at ports, VLANs, etc.)
- is the external network / fabric properly configured, so all hosts have access to ports on both controllers?
- what are disk timeouts set to on your hosts / guest VMs?
The best way to prove it works (or doesn't work ) is to actually do the cluster failover.
Regards,
Radek