To update this thread in case anyone searches: I decided to upgrade the server to 5.0P1 and then JUST upgrade to 2008R2 boxes to 5.0P1. My intent was then to upgrade to 6 for everything else. Before I did that, I realized that the PowerShell upgrade is also not compatible with 2012R2 which we have quite a few of (unfortunately). I also took note that both new prerequisites will need to be installed on everything going forward (for now) as neither are preinstalled even on Server 2022. Since this appears to be a major overhaul of SC, I'm going to wait a few patches to deploy.