Hi
It won't work and it will lead your filer to panic mode or it will reboot by itself. because of multiple disks missing from the controller. The safe way to do it without downtime is, remove ownership from all the disk belong to the shelf that you want to remove, power off the shelf and remove the cable.
1) destroy the volume and aggregate (if necessary)
2) remove ownership
3) make sure all the disks belong to the shelf that you want to remove are unowned disks (disk show -n)
4) power off the shelf that you want to remove
5) remove the cable
Regards,
Ye