If fractional reserve is set below 100%, it is possible that volume will run out of space for new writes to LUN from host. Most operating systems do not expect that disk can suddenly run out of space and do not handle this case gracefully.
So you will need to monitor your system for available space and decide in advance what you will do if space becomes dangerously low. Increase volume, delete some snapshots etc.
Which amount can be considered “dangerously low” depends on your environment – how heave IO is, what change rate is, possible peaks of activity etc.