There are some limitations with vfiler (does not support FCP, etc), but SnapDrive definetely works fine with Vfilers.
You just need to setup httpd.admin and ensure the vfiler name is in dns and translates into the IP used for management tasks (SnapDrive will use this ip/hostname for sending ZAPI calls when communicating with the vfiler).
if you see a problem, you need to look into the logs and perhaps log a case.
Kind Regards,
Domenico