I'm using VMDKs from multiple datastores/LUNs/Volumes to create a spanned Windows NTFS volume in a VMware VM.
So machine ServerA has two (2) disks connected - each hosted on separate data stores from different volumes
Disk1 [Datastore01\ServerA.vmdk] 100GB
Disk2 [Datastore02\ServerA.vmdk] 100GB
These disks are spanned to create a single "F:" drive of 200GB
Datastore01 is from the path /vol/Volume01/Lun01
Datastore02 is from the path /vol/Volume02/Lun01
I create a resource group in SnapCenter to backup the VM and include ALL spanned entities
The backup runs and I now have two snapshots.... one on each of the volumes
Volume01 - ServerA_test_12-13-2018_18.104.22.16887
Volume02 - ServerA_test_12-13-2018_22.214.171.12487
Judging by the identical snapshot names, it appears both volumes were quiesced for snapshots simultaneously to ensure a consistent snap - thus allowing for a supported method for restoring files from a spanned drive.
I haven't found specific wording in the SnapCenter or other documentation ...so I was hoping that one of my fellow community members could either confirm or refute this practice.