In all honesty, it's a bit hairy subject
VSC consistency relies on VMware snapshots. These in turn are quite often temperamental, so in many cases VMware snapshots for VSC backups are turned off anyway. So the end result is "a" snapshot, as good, as any other taken on the filer side. Also, a crash-consistent backup of OS partition will work just fine in most cases - it is like pulling a plug suddenly from a server, running check disk may be required, but in principle it should work. It is a different story for databases and/or mail stores, where ideal approach is to use relevant SnapManager product. For Microsoft apps though VSC can potentially do data consistency as well via VMware tools & VSS integration, but it can't do more advanced stuff like log trimming.
That said, using VSC offers some other benefits for OS backups, like scheduling, backup catalogue, etc.
Regards,
Radek