Hi
I think that the answer is depend on your circumstances.
If you can get the same (or acceptable) performance and availability with other protocol that been proven or theoretically more fit - that's a win.
Beside MPIO that was mentioned before. I do want to add that by doing that you're moving what now been your point of failure - to another; Windows clustering... in the last few years iv'e seen the CMS process crashes, indefinite WMI leaks (some recovered gracefully, required a VM shutdown or just crashed) and lot's of finger pointing between software and hardware vendor when these go south. yes - the majority is for a single host and not affected the whole cluster, but I did see a few that did.