That is 2 questions in one although they might be connected.
Both, System Manager and NMC are client programs you can install somewhere. System Manager connects to Ontap as Alex described.
NMC connects to Unified Manager Server to Manage Backups in ONTAP.
Both problems could be caused by settings in ONTAP or Network or settings on the client. The documentation says which ports are in use. In the ideal case you would make sure that all the preferences in the documentation are met.
If this is the case opening a support case is probably the easiest way of solving it.