You can go ahead and start de-duplication on the source volume.
Make sure you have enough space on the source and good WAN bandwidth as after de-duplication finishes, A-SIS will generate a snapshot (depends on the size of the volume) which will be transferred to the destinatio site via VSM, same as your source filer snapshots.
After this transfer completes, you will see the destination volume showing as "snapmirrroed, online, sis".
After 1st de-duplication, run the same every quater (if the increamental changes are not large). Everytime, it will generate snapshot of A-SIS and the same will be replicated to the destination filer ans so on.