You can’t change the serial number after the initial configuration.
Boot the simulator again.
When you see Hit [Enter] to boot immediately, or any other key for command prompt, hit Ctrl-C.
You will then enter the SIMLOADER prompt.
Enter the following commands to set your unique serial number.
1. set bootarg.nvram.sysid=1111111101
2. set SYS_SERIAL_NUM=1111111101
3. boot