Thanks Schrie for your reply.
I am already aware of using Optimized Datastore to negate the misalignment but I can't use it as we don't have any additional space to create new Datastore.
I just wanted to clarify my understanding of using the MBRAlign on Windows with multiple drives.
Can't use the VMware converter as well !
Dirk doc's looks very informative.
BTW: your blog needs some updates!