Edge is tuned for production workloads and has support. The vsim is optimized for test & dev.
Some of that tuning includes:
Fixed sizing requirements (ram, vcpu count, etc)
Virtual SAS disk subsystem
RAID0 - leveraging physical raid controller for redundancy
VNVRAM - leveraging physical raid controller BBWC
no CPU halt on idle
ESX is a requirement, desktop hypervisors will not work.
and features that don't work in a VM are disabled (fc commands, etc)